Twenty plant species belonging to 15 families were selected in this study on the basis of their uses in Hausa and Kanuri folk medicine to cure malaria and cancer. Extracts prepared from the plants were solvent portioned and screened for activity in the brine shrimp (

Artemia salina -Leach) lethality test (BST). Aqueous and ethyl acetate extracts of the roots of Cochlospermum tinctorium A. Rich and the chloroform soluble fraction (F2) of stem bark of Entada sudanica Schweinf exhibited very high lethality on brine shrimp larvae at LC50 values 8(26-3), 10(32-6), and 6(15-0) respectively. Sclerocarya birrea, Momordica charantia, Boerhaavia diffusa and Nauclea aculeata extracts have exhibited potent activity at LC50 values